Table of Contents
At Online Doctor SA, we believe healthy, youthful skin should be attainable – no matter your age. That’s why we offer convenient online prescriptions for powerful, evidence-based anti-aging treatments like topical tretinoin and adapalene..
If you’re looking to reduce fine lines, smooth rough skin, and boost your glow, these dermatologist-approved treatments may be the solution you’ve been waiting for.
What is Tretinoin?

Tretinoin (a form of vitamin A) is a potent topical retinoid that stimulates collagen production, speeds up skin cell turnover, and helps reduce fine lines, pigmentation, and sun damage. It is often considered the gold standard in anti-aging skincare.
Originally developed to treat acne, dermatologists quickly noticed its powerful anti-aging benefits. With consistent use, tretinoin can:
- Improve skin texture and tone
- Reduce the appearance of wrinkles and sun spots
- Prevent clogged pores and breakouts
- Restore a more youthful complexion over time
What is Adapalene?

Adapalene is a gentler form of retinoid that also increases cell turnover and reduces inflammation. It is ideal for sensitive skin or those starting retinoid treatment for the first time. While it is often used for acne, adapalene also helps with:
- Fading fine lines and pigmentation
- Preventing breakouts in adult skin
- Smoothing texture without excessive irritation
Get Prescribed Online
Online Doctor SA offers a seamless telemedicine process:
- Complete the clinical form
- Await assessment from our registered doctors
- Receive your prescription to your email. Use your prescription at any pharmacy in South Africa.
Whether you are starting your anti-aging journey or switching up your skincare routine, we will help you do it safely and conveniently.
Tretinoin vs Adapalene: Which One Should I Choose?
| Feature | Tretinoin | Adapalene |
| Strength | Prescription only – very potent | Prescription only – less potent |
| Irritation risk | Higher (especially at first) | Lower and more tolerable |
| Ideal for | Moderate to advanced photoaging | Mild signs of aging/sensitive skin |
| Time to see results | 3 – 6 months | 3 – 6 months |
Important Tips Before Starting Retinoids
- Always wear sunscreen: Retinoids increase your skin’s sensitivity to the sun. SPF 30+ is essential. Higher SPF e.g. SPF 50 is necessary for lighter skin tones.
- Start slow: Begin with 2 – 3 nights a week and gradually increase as tolerated.
- Moisturise: Use a gentle, fragrance-free moisturiser to reduce dryness or irritation.
- Avoid harsh exfoliants: Use gentle cleansers to avoid skin irritation.

Ready to Start Your Anti-Aging Journey?
Visit Online Doctor SA to complete your skin assessment and get prescribed today. Experience proven skincare with the convenience of telemedicine – and reveal your most confident skin yet.
How do I get a prescription for tretinoin or adapalene?
Simply complete the Online Doctor SA clinical form and await assessment from our registered doctors. Receive your prescription directly to your email. Use your prescription at any pharmacy in South Africa to purchase the medication.
Can I use tretinoin or adapalene if I don’t have acne?
Yes. Both are highly effective for anti-aging, even if you don’t have breakouts.
How long before I see results?
Most people notice smoother skin in 8-12 weeks, with full results in 3-6 months. Patience is key.
What are the common side effects?
Dryness, peeling, redness, or mild irritation – especially in the first few weeks. These effects are normal and usually settle with continued use.
Can I use these products with other skincare?
Yes, but be cautious. Avoid using them with strong exfoliants at the same time.
Is it safe to use retinoids long-term?
Yes. In fact, long-term use is what delivers the best anti-aging benefits. Just be consistent and protect your skin from the sun.
Can I use these products if I’m pregnant or breastfeeding?
No. Retinoids are not recommended during pregnancy or breastfeeding. Let us know if you’re pregnant or planning to conceive.