What is Post-Exposure Prophylaxis (PEP)?
Post-Exposure Prophylaxis (PEP) is a short-term medical treatment designed to reduce the likelihood of HIV infection after potential exposure. PEP involves taking antiretroviral medication (ARVs) for 4 weeks. It is most effective when started as soon as possible, ideally within 72 hours of exposure.

When Should You Consider PEP?
PEP is recommended in situations where there is a significant risk of HIV exposure, such as:
- Unprotected sexual intercourse (including condom failure) with a partner of unknown HIV status or known to be HIV-positive.
- Needle-stick injuries, especially for healthcare workers.
- Unsafe practices eg. needle sharing during drug use.
- Sexual assault.
If you believe you have been exposed to HIV, it is crucial to act quickly and seek medical advice immediately.

How Does PEP Work?
PEP uses a combination of antiretroviral drugs to prevent the virus from taking hold in your body. These medications inhibit the replication of the virus, reducing the chance of it establishing a permanent infection.
To be effective:
- Start PEP within 72 hours of exposure – sooner is better. In high-risk cases, PEP may still be considered up to 7 days after exposure, but effectiveness decreases after 3 days.
- Take the prescribed medication every day for 28 days without missing a dose.
Where Can You Get PEP?
Online Doctor SA – quickly receive your prescription for PEP. The prescription is emailed to you discreetly. Use your prescription at any pharmacy to purchase the medication.
- Please note that this emergency prescription does not constitute the full management of being exposed to HIV.
- As a patient who has been potentially exposed to HIV, you still need to be fully assessed at your local medical facility. This includes examination, blood tests and counselling.
- The complete management determines if it is safe for you to take the ARVs, and ensures that you don’t develop STIs, hepatitis, kidney damage, liver damage, or that you don’t fall pregnant.
Alternatively, access PEP from:
- Public healthcare facilities – clinics and hospitals.
- Private healthcare providers – sexual health clinics or through your in-person doctor.
What to Expect During PEP Treatment
While taking PEP, you may experience common side effects such as:
- Nausea
- Fatigue
- Diarrhea
These side effects are usually manageable and temporary. If they persist or worsen, consult your healthcare provider.
Other more severe side effects include:
- Kidney damage
- Liver damage
- Pancreatitis
- Allergic reactions
Key Points to Remember
- Start PEP as soon as possible, within 72 hours of exposure.
- Ensure you take all the medication for 28 days to maximize effectiveness.
- Urgently visit your local clinic for complete management.
- Your local clinic will schedule follow-up HIV tests after exposure to monitor and confirm your status.
Prevention is Better Than Cure
While PEP is a valuable tool, it should not replace primary prevention strategies such as:
- Consistent use of condoms.
- Following the manufacturer’s recommendations to prevent condoms from breaking.
- Using PrEP (Pre-Exposure Prophylaxis) if you are at ongoing risk of HIV exposure.
- Avoiding the sharing of needles.

How to Seek Help
If you think you may need PEP, do not delay. To quickly receive a prescription for PEP, use Online Doctor SA, or contact your nearest healthcare provider or emergency department immediately for assistance. Early action can make all the difference in protecting your health.