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Post-Exposure Prophylaxis (PEP): What You Need to Know + 17 Frequently Asked Questions

Online Doctor South africa post exposure prophylaxis PEP 2

What is Post-Exposure Prophylaxis (PEP)?

Post-Exposure Prophylaxis (PEP) is a short-term medical treatment designed to reduce the likelihood of HIV infection after potential exposure. PEP involves taking antiretroviral medication (ARVs) for 4 weeks. It is most effective when started as soon as possible, ideally within 72 hours of exposure.

Online Doctor South africa post exposure prophylaxis PEP 2

When Should You Consider PEP?

PEP is recommended in situations where there is a significant risk of HIV exposure, such as:

  • Unprotected sexual intercourse (including condom failure) with a partner of unknown HIV status or known to be HIV-positive.
  • Needle-stick injuries, especially for healthcare workers.
  • Unsafe practices eg. needle sharing during drug use.
  • Sexual assault.

If you believe you have been exposed to HIV, it is crucial to act quickly and seek medical advice immediately.

Online Doctor South africa post exposure prophylaxis PEP 2

How Does PEP Work?

PEP uses a combination of antiretroviral drugs to prevent the virus from taking hold in your body. These medications inhibit the replication of the virus, reducing the chance of it establishing a permanent infection.

To be effective:

  • Start PEP within 72 hours of exposure – sooner is better. In high-risk cases, PEP may still be considered up to 7 days after exposure, but effectiveness decreases after 3 days.
  • Take the prescribed medication every day for 28 days without missing a dose.

Where Can You Get PEP?

Online Doctor SA – quickly receive your prescription for PEP. The prescription is emailed to you discreetly. Use your prescription at any pharmacy to purchase the medication. 

  • Please note that this emergency prescription does not constitute the full management of being exposed to HIV.
  • As a patient who has been potentially exposed to HIV, you still need to be fully assessed at your local medical facility. This includes examination, blood tests and counselling. 
  • The complete management determines if it is safe for you to take the ARVs, and ensures that you don’t develop STIs, hepatitis, kidney damage, liver damage, or that you don’t fall pregnant.

Alternatively, access PEP from:

  • Public healthcare facilities – clinics and hospitals.
  • Private healthcare providers – sexual health clinics or through your in-person doctor.

What to Expect During PEP Treatment

While taking PEP, you may experience common side effects such as:

  • Nausea
  • Fatigue
  • Diarrhea

These side effects are usually manageable and temporary. If they persist or worsen, consult your healthcare provider.

Other more severe side effects include:

  • Kidney damage
  • Liver damage
  • Pancreatitis
  • Allergic reactions

Key Points to Remember

  1. Start PEP as soon as possible, within 72 hours of exposure.
  2. Ensure you take all the medication for 28 days to maximize effectiveness.
  3. Urgently visit your local clinic for complete management.
  4. Your local clinic will schedule follow-up HIV tests after exposure to monitor and confirm your status.

Prevention is Better Than Cure

While PEP is a valuable tool, it should not replace primary prevention strategies such as:

  • Consistent use of condoms.
  • Following the manufacturer’s recommendations to prevent condoms from breaking.
  • Using PrEP (Pre-Exposure Prophylaxis) if you are at ongoing risk of HIV exposure.
  • Avoiding the sharing of needles.
Online Doctor South africa post exposure prophylaxis PEP

How to Seek Help

If you think you may need PEP, do not delay. To quickly receive a prescription for PEP, use Online Doctor SA, or contact your nearest healthcare provider or emergency department immediately for assistance. Early action can make all the difference in protecting your health.


Click here to quickly receive a prescription for PEP from Online Doctor SA: https://onlinedoctorsa.co.za/product/post-exposure-prophylaxis-pep/


PEP (Post-Exposure Prophylaxis) Frequently asked Questions – FAQ

  1. What is PEP (Post-Exposure Prophylaxis)?

    PEP is a short-term course of HIV prevention medication taken within 72 hours of potential exposure to HIV to reduce the risk of infection. It involves a combination of antiretroviral drugs prescribed by a healthcare provider.

  2. Who should consider taking PEP?

    PEP is recommended for individuals who may have been recently exposed to HIV through unprotected sex, sharing needles, or in cases of occupational exposure, such as needlestick injuries. It’s also considered after sexual assault if HIV exposure is a concern.

  3. How soon do I need to start PEP after possible HIV exposure?

    PEP must be started within 72 hours of potential exposure to HIV for maximum effectiveness. The sooner you start, the better it works. In certain high-risk cases, it may still be considered up to 7 days after exposure, but the success rate decreases.

  4. How does PEP work?

    PEP involves taking antiretroviral medication (ARVs) daily for 28 days. These drugs help prevent the virus from replicating in your body, significantly reducing the risk of HIV infection.

  5. Is PEP 100% effective?

    PEP is highly effective when started promptly and taken as prescribed, but it is not guaranteed to prevent HIV infection. It’s important to follow the full course and attend follow-up appointments.

  6. Can I get a PEP prescription online?

    Yes, Online Doctor SA offers quick, discreet prescriptions for emergency PEP. Our on-call doctors are ready to assess and provide you with a prescription for PEP, 24/7.

  7. What are the side effects of PEP?

    Common side effects include nausea, fatigue, and headaches. These are usually mild and temporary. Severe side effects are rare but include liver damage, kidney damage, pancreatitis, allergic reactions. It is essential to be properly assessed and monitored while on PEP.

  8. What happens if I miss a dose of PEP?

    If you miss a dose, take it as soon as you remember. Missing doses can reduce the effectiveness of PEP, so try to adhere strictly to the prescribed schedule.

  9. Can I stop PEP if I feel fine after a few days?

    No, you should complete the full 28-day course even if you feel fine. Stopping early may increase your risk of HIV infection.

  10. Is PEP available without a prescription in South Africa?

    No, PEP requires a prescription from a qualified healthcare provider in South Africa. Online Doctor SA makes it simple to quickly receive an emergency PEP prescription.

  11. Does medical aid cover PEP?

    Many medical aids in South Africa cover PEP under their HIV prevention benefits. Check with your provider for details. You can submit your Online Doctor SA invoice to your medical aid for possible reimbursement, depending on your medical aid plan.

  12. How much does PEP cost?

    The cost of a prescription for PEP (post-exposure prophylaxis) is R250 with Online Doctor SA. Use your Online Doctor SA prescription at any pharmacy to purchase the medication. The cost of the PEP medication is pharmacy dependent.

  13. Can PEP protect against other sexually transmitted infections (STIs)?

    PEP only reduces the risk of HIV infection. It does not protect against other STIs. It is essential to have a full medical assessment for safety.

  14. How do I get a prescription for PEP?

    Visit www.onlinedoctorsa.co.za and complete the PEP online consultation. One of our HPCSA registered doctors will assess your case and quickly provide you with a prescription if appropriate. Use your prescription at any pharmacy to purchase the PEP medication.

  15. What should I do if I miss the 72-hour window for starting PEP?

    If you miss the 72-hour window but your exposure is high-risk, PEP may still be considered up to 7 days after exposure. Urgently visit your local clinic or doctor for management.

  16. Where can I get a prescription for PEP in South Africa?

    Easily receive a prescription for PEP (post-exposure prophylaxis) with Online Doctor SA. Simply visit www.onlinedoctorsa.co.za, choose the PEP option and complete the clinical form. Our on-call doctors will quickly and discreetly assess and send you the prescription via email. Use your prescription at any pharmacy in South Africa to purchase the medication

  17. How much does it cost to get a PEP prescription online?

    The cost to receive a prescription for PEP (post-exposure prophylaxis) is R250 with Online Doctor SA. Use your prescription at any pharmacy in South Africa to purchase the medication.

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